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![]() ![]() Key search words were & amp amp amp #39 Asperger& amp amp amp #39, & amp amp amp #39 high functioning autism& amp amp amp #39, & amp amp amp #39 autism spectrum disorders (ASD)& amp amp amp #39, and & amp amp amp #39 pervasive developmental disorder (PDD)& amp amp amp #39 in combination with & amp amp amp #39 second generation antipsychotics& amp amp amp #39, & amp amp amp #39 aripiprazole & amp amp amp #39 olanzapine& amp amp amp #39, & amp amp amp #39 quetiapine& amp amp amp #39, & amp amp amp #39 risperidone& amp amp amp #39, or & amp amp amp #39 ziprasidone& amp amp amp #39. We conducted a systematic review and meta-analysis of the recent English literature on SGA use in children and adolescents (ages 0-24 years) with AD and HFA using the Medline/PubMed and PsychINFO computerized databases. There is a need to review the published literature on SGA treatment efficacy in the AD and HFA populations to provide more effective treatment choices for these subgroups. Individuals with Asperger& amp amp amp #39 s Disorder (AD) and High Functioning Autism (HFA) experience significant emotional and behavioral problems and psychiatric comorbidity. Second generation antipsychotics (SGA) have gained increased evidence for the treatment of irritability and aggression in children and adolescents with lower functioning autistic disorder. ![]()
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